Tissue processing is a one-way process where a number of chemicals steps and physical conditions will irreversibly determine the suitable processing of the specimen for the morphological (H&E), IHC and molecular analysis. Diagnostic-therapeutic algorithms for the selection of patients for targeted cancer treatment include immunohistochemical and molecular analysis of histological specimens. That’s why the quality of FFPE (Formalin Fixed Paraffin Embedded) specimens processed is mandatory.
Clinical care and Patient management
Pathology Diagnosis
Nucleic Acid (DNA, RNA) and protein expression
Target therapies to slow down or inhibit tumor’ growth
Ana Caramelo BSc1, António Polónia MD, PhD1,2, João Vale MSc1, Mónica Curado BSc1, Sofia Campelos MD1, Vanessa Nascimento BSc1, Mariana Barros BSc1, Diana Ferreira BSc1, Tânia Pereira BSc1, Beatriz Neves BSc1, Catarina Eloy MD PhD1,2,3.
The results of this study suggest that, analytic conditions less often motive of consideration such as tissue processing, may be major culprits in the lack of consistent results of biomarkers evaluation, such as PD-L1. […]
These observations support others reported in the literature that support the urgent need to standardize tissue processing and to review the basic chemistry associated with the biomarkers evaluation, since it has been proved to fail as a solid quantitative method. […]
This study demonstrates the need to review and standardize the tissue processing in pathology laboratories to cope with the growing needs of precision medicine inherent quantifications and the production of high quality material necessary for computational pathology usage.
GREEN SOLUTION - OTTIX
Ottix is Diapath’s patented solution consisting of two reagents replacing the complete alcohol scale and xylene. Through the application of protocols validated and used all over the World for more than ten years, Ottix guarantees better results than traditional reagents, especially when used for processing breast, skin and fatty tissue samples.
ACTIVATED CARBON FILTERS
Donatello® Series 3 has two high performance activated carbon filters for the removal of compound hydrocarbons. The instrument has a suction point, with a dedicated filter, above the processing chamber.
MAXIMUM PRODUCTIVITY
Donatello, thanks to its large processing chamber and its reagent mixing technology, allows to process up to 420 standard biocassettes with a single processing. With the dedicated basket, it is then possible to process up to 112 Slim Mega Cassettes and up to 56 Super Mega Cassettes with a single processing.
FPS - FAST PROCESSING
The FPS (Fast Processing System) is a system that allows the preheating of the reagent in a safe and homogeneous way before its actual use inside the processing chamber. The use of this technology allows for the processing of small biopsies (up to 1 mm thickness) in less than an hour.
Diapath Donatello Series Automatic Tissue Processor is Silver Winner of A’Design Award and Competition in Scientific Instruments, Medical Devices and Research Equipment Design Category.
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Complete control of reagents and activated carbons
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